Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC050
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-01-05 07:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 4x1/4 this is not NMC050, it is NMC049!!! old patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.016
timePerCircleCoV 0.18341
timePerCircleSlope -0.0547956
meanError 1.77387
tremorFreq 5.85938
tremorRelPower 31.0871
tremorGyroAmpMean 0.0234654
tremorGyroAmpSlope 0.00292872
tremorGyroAmpCoV 0.399239
tremorCoordAmpMean 0.0476795
tremorCoordAmpSlope 0.0026359
tremorCoordAmpCoV 0.317474
tremorAccAmpMean 0.0560729
tremorAccAmpSlope 0.00130622
tremorAccAmpCoV 0.17001
tremorPcRelVar 0.606248
tremorPcX -0.0621175
tremorPcY -0.998069

Circle Segment 1

Duration 15.96 s, Accuracy Estimate 1.798 (lower is better)

Circle Segment 2

Duration 14.72 s, Accuracy Estimate 1.264 (lower is better)

Circle Segment 3

Duration 14.04 s, Accuracy Estimate 1.112 (lower is better)

Circle Segment 4

Duration 12.72 s, Accuracy Estimate 1.462 (lower is better)

Circle Segment 5

Duration 10.12 s, Accuracy Estimate 1.564 (lower is better)

Circle Segment 6

Duration 10.88 s, Accuracy Estimate 2.004 (lower is better)

Circle Segment 7

Duration 11.0 s, Accuracy Estimate 2.196 (lower is better)

Circle Segment 8

Duration 11.0 s, Accuracy Estimate 1.905 (lower is better)

Circle Segment 9

Duration 9.92 s, Accuracy Estimate 1.498 (lower is better)

Circle Segment 10

Duration 9.8 s, Accuracy Estimate 2.935 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 29.165
timePerSpiralCoV 0.182325
timePerSpiralSlope -0.052754
meanError 4.57652
tremorFreq 5.56641
tremorRelPower 34.619
tremorGyroAmpMean 0.0214668
tremorGyroAmpSlope 0.00121808
tremorGyroAmpCoV 0.433548
tremorCoordAmpMean 0.142521
tremorCoordAmpSlope 0.00749582
tremorCoordAmpCoV 1.48812
tremorAccAmpMean 0.0525095
tremorAccAmpSlope -4.33143e-05
tremorAccAmpCoV 0.192667
tremorPcRelVar 0.615784
tremorPcX 0.0258885
tremorPcY -0.999665

Spiral Segment 1

Duration 35.8 s, Accuracy Estimate 3.396 (lower is better)

Spiral Segment 2

Duration 35.76 s, Accuracy Estimate 3.529 (lower is better)

Spiral Segment 3

Duration 28.68 s, Accuracy Estimate 4.555 (lower is better)

Spiral Segment 4

Duration 33.32 s, Accuracy Estimate 4.349 (lower is better)

Spiral Segment 5

Duration 21.88 s, Accuracy Estimate 7.275 (lower is better)

Spiral Segment 6

Duration 24.2 s, Accuracy Estimate 4.85 (lower is better)

Spiral Segment 7

Duration 25.36 s, Accuracy Estimate 4.051 (lower is better)

Spiral Segment 8

Duration 28.32 s, Accuracy Estimate 4.607 (lower is better)

Elel

eDurationMean 0.907083
eDurationStd 0.47121
eDurationStdnorm 0.519478
eDurationMedian 0.69
eDurationQuartdelta 0.6625
eDurationQuartdeltanorm 0.960145
eDurationKurt 3.9946
eDurationTrenddiff -0.5625
eDurationTrendratio 0.5
eWidthMean 3.783
eWidthStd 2.17842
eWidthStdnorm 0.575845
eWidthMedian 3.1005
eWidthQuartdelta 1.6965
eWidthQuartdeltanorm 0.54717
eWidthKurt 6.98498
eWidthTrenddiff -1.053
eWidthTrendratio 0.709677
eHeightMean 8.3655
eHeightStd 3.75939
eHeightStdnorm 0.449392
eHeightMedian 7.4295
eHeightQuartdelta 2.8665
eHeightQuartdeltanorm 0.385827
eHeightKurt 3.35269
eHeightTrenddiff -1.404
eHeightTrendratio 0.823529
eAspectMean 0.481371
eAspectStd 0.226765
eAspectStdnorm 0.471082
eAspectMedian 0.431677
eAspectQuartdelta 0.29202
eAspectQuartdeltanorm 0.676478
eAspectKurt 5.23491
eAspectTrenddiff -0.0702162
eAspectTrendratio 0.851281
eSlantMean -0.324687
eSlantStd 0.199998
eSlantStdnorm -0.615971
eSlantMedian -0.248188
eSlantQuartdelta 0.31644
eSlantQuartdeltanorm -1.275
eSlantKurt 2.28031
eSlantTrenddiff 0.0114159
eRtopMean 0.44585
eRtopStd 0.22564
eRtopStdnorm 0.506089
eRtopMedian 0.451411
eRtopQuartdelta 0.35938
eRtopQuartdeltanorm 0.796127
eRtopKurt 2.23187
eRtopTrenddiff 0.0506143
eRbotMean 1.29376
eRbotStd 0.493583
eRbotStdnorm 0.381512
eRbotMedian 1.15833
eRbotQuartdelta 0.662462
eRbotQuartdeltanorm 0.57191
eRbotKurt 4.3024
eRbotTrenddiff 0.0901515
eRrightMean 0.626852
eRrightStd 0.180788
eRrightStdnorm 0.288407
eRrightMedian 0.666538
eRrightQuartdelta 0.318572
eRrightQuartdeltanorm 0.47795
eRrightKurt 1.97746
eRrightTrenddiff 0.0747832
eRleftMean 0.619068
eRleftStd 0.209485
eRleftStdnorm 0.338387
eRleftMedian 0.563019
eRleftQuartdelta 0.305559
eRleftQuartdeltanorm 0.542716
eRleftKurt 2.10474
eRleftTrenddiff -0.0550971
lDurationMean 1.17579
lDurationStd 0.491888
lDurationStdnorm 0.418347
lDurationMedian 1.11
lDurationQuartdelta 0.6625
lDurationQuartdeltanorm 0.596847
lDurationKurt 3.23373
lDurationTrenddiff -0.56
lDurationTrendratio 0.589744
lWidthMean 3.95337
lWidthStd 1.48281
lWidthStdnorm 0.375075
lWidthMedian 3.744
lWidthQuartdelta 1.404
lWidthQuartdeltanorm 0.375
lWidthKurt 8.20715
lWidthTrenddiff -0.468
lWidthTrendratio 0.878788
lHeightMean 12.5744
lHeightStd 4.52625
lHeightStdnorm 0.359957
lHeightMedian 11.583
lHeightQuartdelta 4.76775
lHeightQuartdeltanorm 0.411616
lHeightKurt 4.55223
lHeightTrenddiff -2.457
lHeightTrendratio 0.814159
lAspectMean 0.351652
lAspectStd 0.188195
lAspectStdnorm 0.535173
lAspectMedian 0.30303
lAspectQuartdelta 0.149087
lAspectQuartdeltanorm 0.491986
lAspectKurt 4.23825
lAspectTrenddiff 0.031656
lAspectTrendratio 1.10964
lSlantMean -0.304225
lSlantStd 0.172492
lSlantStdnorm -0.566988
lSlantMedian -0.310345
lSlantQuartdelta 0.157771
lSlantQuartdeltanorm -0.508373
lSlantKurt 4.80782
lSlantTrenddiff -0.0652003
lRtopMean 0.306166
lRtopStd 0.151645
lRtopStdnorm 0.495303
lRtopMedian 0.27027
lRtopQuartdelta 0.212737
lRtopQuartdeltanorm 0.787129
lRtopKurt 2.43776
lRtopTrenddiff 0.00606061
lRbotMean 1.36529
lRbotStd 0.445875
lRbotStdnorm 0.32658
lRbotMedian 1.36
lRbotQuartdelta 0.735134
lRbotQuartdeltanorm 0.54054
lRbotKurt 2.12724
lRbotTrenddiff 0.157241
lRrightMean 0.54833
lRrightStd 0.158136
lRrightStdnorm 0.288396
lRrightMedian 0.57971
lRrightQuartdelta 0.165365
lRrightQuartdeltanorm 0.285254
lRrightKurt 3.32739
lRrightTrenddiff 0.0289855
lRleftMean 0.775297
lRleftStd 0.13432
lRleftStdnorm 0.173249
lRleftMedian 0.802752
lRleftQuartdelta 0.167602
lRleftQuartdeltanorm 0.208784
lRleftKurt 3.10193
lRleftTrenddiff -0.0452311

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

FITTS Short Modified

meanTouchScore 0.855927
sumTouchScores 17.1185
meanMovementTime 0.953684
numTouches 20
undershootPercentage 35
overshootPercentage 10

FITTS Long Modified

meanTouchScore 0.933333
sumTouchScores 14
meanMovementTime 1.19143
numTouches 15
undershootPercentage 6.66667
overshootPercentage 0

ZigZag

numZigzags 8
timePerZigzagMean 25.88
timePerZigzagCoV 0.246871
timePerZigzagSlope -0.071171
meanError 2.16969
tremorFreq 5.95703
tremorRelPower 20.8074
tremorGyroAmpMean 0.0268961
tremorGyroAmpSlope 0.00265904
tremorGyroAmpCoV 0.440453
tremorCoordAmpMean 0.0510545
tremorCoordAmpSlope 0.000676553
tremorCoordAmpCoV 0.30278
tremorAccAmpMean 0.0408863
tremorAccAmpSlope 0.000845568
tremorAccAmpCoV 0.350003
tremorPcRelVar 0.671855
tremorPcX 0.235768
tremorPcY -0.971809

ZigZag Segment 1

Duration 35.04 s, Accuracy Estimate 3.337 (lower is better)

ZigZag Segment 2

Duration 27.44 s, Accuracy Estimate 2.437 (lower is better)

ZigZag Segment 3

Duration 36.08 s, Accuracy Estimate 1.986 (lower is better)

ZigZag Segment 4

Duration 20.52 s, Accuracy Estimate 1.846 (lower is better)

ZigZag Segment 5

Duration 20.24 s, Accuracy Estimate 2.166 (lower is better)

ZigZag Segment 6

Duration 22.68 s, Accuracy Estimate 1.866 (lower is better)

ZigZag Segment 7

Duration 23.52 s, Accuracy Estimate 1.946 (lower is better)

ZigZag Segment 8

Duration 21.52 s, Accuracy Estimate 1.773 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.176
timePerZigzagCoV 0.121955
timePerZigzagSlope -0.0664845
zigzagHeightMean 66.564
zigzagHeightCoV 0.0346323
zigzagHeightSlope -0.00711393
meanError 0.0384686
tremorFreq 6.05469
tremorRelPower 30.9112
tremorGyroAmpMean 0.0758662
tremorGyroAmpSlope -0.0132336
tremorGyroAmpCoV 0.474886
tremorCoordAmpMean 0.101361
tremorCoordAmpSlope -0.00419842
tremorCoordAmpCoV 0.319121
tremorAccAmpMean 0.0796573
tremorAccAmpSlope -0.00467858
tremorAccAmpCoV 0.336104
tremorPcRelVar 0.852949
tremorPcX 0.0140684
tremorPcY -0.999901

ZigZag Offset Segment 1

Duration 15.92 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 2

Duration 12.92 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 12.72 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 4

Duration 12.64 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 5

Duration 11.68 s, Accuracy Estimate 0.053 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.3}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.914211618052813}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8802329275647527}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8228163993316099}